Adenosylcobyric acid synthase (glutamine-hydrolysing)

adenosylcobyric acid synthase (glutamine-hydrolyzing)
Identifiers
EC number 6.3.5.10
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an adenosylcobyric acid synthase (glutamine-hydrolysing) (EC 6.3.5.10) is an enzyme that catalyzes the chemical reaction

4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O \rightleftharpoons 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

The 4 substrates of this enzyme are ATP, adenosylcobyrinic acid a,c-diamide, L-glutamine, and H2O, whereas its 4 products are ADP, phosphate, adenosylcobyric acid, and L-glutamate.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds carbon-nitrogen ligases with glutamine as amido-N-donor. The systematic name of this enzyme class is adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase (ADP-forming). Other names in common use include CobQ, cobyric acid synthase, 5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine, amido-ligase, and Ado-cobyric acid synthase [glutamine hydrolyzing]. This enzyme participates in porphyrin and chlorophyll metabolism.

References